Catherine Keener was born in Miami, Florida, where she attended Catholic
schools. She went to Wheaton College and studied English and history.
Keener broke into films with one line in About Last Night (1986). She guest-starred as an artist on an episode of Seinfeld called "The Letter". She played Jerry's girlfriend, an artist who painted the infamous portrait of Kramer.
Catherine Keener was nominated for an Academy Award in 2000 for her role in Being John Malkovich but the award was given to Angelina Jolie. She also starred in the 2005 political thriller The Interpreter, and was the woman to whom Andy (Steve Carell) lost his virginity in The 40-Year-Old Virgin.
Keener gave a memorable performance as Harper Lee in Capote (2005), and in January 2006 was nominated for an Academy Award for Best Supporting Actress for the role. The award went to Rachel Weisz.
Catherine Keener has been married to actor Dermot Mulroney for 15 years, although the couple separated in September 2005. They have a son named Clyde.
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